Combine an eye of round roast and onions with a spicy sauce of ketchup, brown sugar, hot sauce, chili powder and other spices, and cook in the slow cooker for a hearty main dish.
Cut roast in half, and place in a 5-quart slow cooker. Stir together ingredients for Spicy Sauce, and pour mixture over uncooked roast. Cook at HIGH 9 hours; remove roast.
Cool slightly, and cut into thin slices. Return slices to slow cooker, and cook 1 more hour.