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This recipe is intended for entertainment purposes only, though the flavor isn’t horrible. Also, the Pepto remains active even after being baked, so it really does make a nice dessert option for anyone experiencing heartburn, indigestion, you know the drill. For an extra bright cake, use 1/2 cup Ultra Pepto and 1/2 cup water in the cake mix.

Recipe by Well Done


Read the full recipe after the video.

Recipe Summary

35 mins
2 hrs 30 mins
Serves 12




Instructions Checklist
  • Preheat oven to 350°F. Lightly coat the bottom of 3 (8-inch) round cake pans with baking spray or shortening.

  • Prepare the Cake: Beat together cake mix, Pepto Bismol, oil, and egg whites in the bowl of a stand mixer fitted with a paddle attachment on medium speed for 3 minutes. Pour batter into prepared pans, and bake in preheated oven until a toothpick inserted in middle comes out clean, about 23 minutes. Let cool on a wire rack in pan 10 minutes; remove from pan to cool completely, about 30 minutes.  

  • Place 1 layer on a serving plate, and spread 1/2 cup icing over top. Repeat with remaining 2 layers. Spread a light coating of icing over entire cake as a crumb coat. Chill 30 minutes.

  • Spread remaining icing over cake, creating a super smooth surface. Chill at least 30 minutes.

  • Prepare the Glaze: Whisk together Pepto Bismol Ultra and 1 cup of the powdered sugar in a medium bowl until smooth. Add remaining powdered sugar, 1/2 cup at a time, until glaze is smooth. Pour glaze over top of cake, and allow it to drip down sides. Garnish with tablets.