Bring brisket, 2 gallons water, and 3 tablespoons pickling spice to a boil in a stockpot; reduce heat, and simmer for 2 1/2 hours. Drain; cover and chill brisket 8 hours.
Place brisket in a lightly greased shallow roasting pan.
Stir together 1 cup ketchup and next 3 ingredients. Drizzle one-third of sauce over brisket.
Bake brisket at 350° for 3 hours, basting every hour with remaining sauce.
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