How to Make It
To make the dough, combine the yeast and grapefruit juice in a large mixing bowl; let stand until foamy, about 5 minutes.
Add sugar, butter, salt, and egg to bowl; beat with an electric mixer until smooth. Add bread flour, beating until smooth. Add all-purpose flour, mixing until a smooth, soft dough forms (add another 1/4 cup of all-purpose flour if the dough is too wet to touch without it sticking to your hand).
Transfer dough to a large, well-greased bowl, turning to coat. Cover and let the dough rise in a warm, draft-free place until it’s doubled in size, 1 to 1 1/2 hours.
While the dough rises, prepare the filling. Combine brown sugar, pistachios, ginger, cardamon, cinnamon, and salt in a food processor; pulse until pistachios are coarsely chopped and all ingredients are well combined. Melt 6 tablespoons of unsalted butter in the microwave or in a small saucepan on the stovetop over medium-low heat.
Punch dough down and turn out onto a lightly floured surface. Roll the dough with a lightly floured rolling pin into a 9- x 15-inch rectangle. Brush the surface of the dough evenly with the 6 tablespoons melted butter; sprinkle evenly with the brown sugar mixture, leaving a 1/2 inch border.
Starting at 1 (15-inch) side, gently roll the dough into a cylinder; cut into 12 even slices. Place the slices in a greased 9-inch round pan or cast-iron skillet. Cover and let rise in a warm, draft-free place until doubled in size, about 30 minutes.
Preheat oven to 350°. Uncover dough and bake at 350° for 25 to 30 minutes or until golden brown. Let stand 5 minutes.
To prepare the glaze, place cream cheese in a mixing bowl. Combine 1/2 cup juice and granulated sugar in a small saucepan over medium-high heat. Bring mixture to a boil, swirling occasionally; reduce heat to medium and simmer until mixture is reduced to about 2 tablespoons. Pour grapefruit mixture over cream cheese; beat with an electric mixer until smooth. Beat in powdered sugar. Beat in remaining 2 tablespoons grapefruit juice. Pour glaze over warm cinnamon rolls and serve.