Preheat oven to 400 degrees. Grease a 9x13" baking dish.
Brown ground beef in a large, deep skillet over medium high heat. Stir in pepperoni.
Drain excess fat. Stir in pizza sauce.
Remove from heat and set aside.
Cut bisuits into quarters, and place in the bottom of greased baking dish.
Spread meat mixture evenly over the biscuits. Top with onion and other veggies.
Bake uncovered in preheated oven for 20-25 minutes.
Sprinkle top with mozzarella and Cheddar cheese. Bake an additional 5 to 10 minutes, until cheese is melted. Let stand 10 minutes before serving.
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