1. Combine first 3 ingredients in a small bowl, stirring well to blend. Set aside.
2. Combine turkey and next 3 ingredients. Divide turkey mixture into 4 equal portions, shaping each into a 1/2-inch-thick patty.
3. Heat a large nonstick skillet over medium heat. Coat pan with cooking spray. Add patties; cook 3 to 4 minutes on each side or until a thermometer registers 165°.
4. Place 1 lettuce leaf on bottom half of each bun; top each with 1 patty and 2 tablespoons cranberry mixture. Top each with 1 bun top.
For this recipe, select ground turkey breast over ground turkey, which contains both the dark and white meat. The breast meat is much lower in calories and fat.