Stir together pie filling, strawberries, and 2 tablespoons flour. Stir in vanilla extract. Place in a lightly greased 8-inch-square baking dish.
Trim crusts from bread slices; cut each slice into 5 strips. Arrange bread strips over fruit mixture.
Stir together remaining 2 tablespoons flour, sugar, and next 4 ingredients; drizzle over bread strips.
Bake at 350° for 35 to 45 minutes or until golden and bubbly.