Combine berries and 1/4 cup sugar in a 2-quart baking dish coated with cooking spray. Stir lightly; sprinkle with vanilla.
Combine flour, brown sugar, and pumpkin pie spice in a medium bowl. Cut in margarine with a pastry blender until mixture resembles coarse meal. Add oats; toss well. Sprinkle topping over berry mixture.
Bake, uncovered, at 400° for 30 minutes. Serve warm.