In a slow cooker, place onion, peppers, mushrooms and chuck roast.
In a small bowl, combine basil, oregano, thyme, garlic and pepper; evenly sprinkle over meat.
In a medium bowl, add water, wine, vinegar and Roasted Beef Base; stir until base dissolves and pour over meat.
Cover and cook on low for 8 hours or until meat is fork tender.
Place meat in bowl with broth. Serve with Italian bread and shredded cheese.
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