Combine flour and sugar in a large bowl; make a well in center of mixture. Combine buttermilk and next 3 ingredients; stir well. Add to dry ingredients, stirring just until dry ingredients are moistened.
Spoon about 2 tablespoons batter into each of 12 muffin cups coated with cooking spray. Place 1 teaspoon jelly in center of each; top with remaining batter.
Bake at 400° for 16 minutes or until muffins spring back when lightly touched in center.
Remove muffins from pan immediately; cool on a wire rack.