1. Preheat oven to 400ºF. Line a baking sheet with foil and mist with cooking spray. Mash bread together with milk in a large bowl until smooth.
2. Add turkey, Parmesan, parsley, eggs, salt, onion and garlic powders, oregano and 2 Tbsp. ketchup to bowl; mix well. Form into a 9-by-5-inch loaf on baking sheet. Spread remaining ketchup on top.
3. Bake until an instant-read thermometer inserted into center of meat loaf registers 165ºF, 45 to 50 minutes. Turn broiler to high and broil meat loaf to crisp exterior, 1 to 3 minutes. Let stand 10 minutes before slicing and serving.