Preheat oven to 400°.
Place bread in a food processor; pulse 10 times or until coarse crumbs measure 1 1/4 cups.
Combine crumbs and next 5 ingredients in a small bowl; stir in butter and set aside. Combine mayonnaise and 1 tablespoon lemon juice.
Place fillets on a broiler pan coated with cooking spray. Sprinkle with salt, pepper, and remaining lemon juice. Spread mayonnaise mixture evenly over fillets; top evenly with crumb mixture.
Bake at 400° for 12 to 15 minutes or until fish flakes easily when tested with a fork. Serve with lemon wedges.