Combine first 4 ingredients in a medium saucepan. Bring to a boil over medium heat; cook 1 minute or until thickened and bubbly. Chill 45 minutes or until completely cooled, stirring occasionally.
Combine pudding mix and milk in a large bowl; whisk 2 minutes or until thickened.
Place one-third of pound cake cubes in a 3-quart trifle bowl; drizzle with 2 tablespoons liqueur. Top with one-third of cranberry-orange sauce and one-third of pudding. Sprinkle with 1/2 cup coconut.
Repeat layers twice using remaining cake cubes, orange liqueur, cranberry-orange sauce, pudding, and coconut, reserving last 1/2 cup coconut for garnish.
Spread whipped topping over trifle. Sprinkle with reserved coconut. Cover and chill at least 4 hours.