Preheat oven to 350°.
Combine first 4 ingredients in a small bowl.
Place bread in a food processor; process until finely ground. Combine bread and milk in a large bowl. Add 1/2 cup ketchup mixture, onion, and the next 9 ingredients (onion through egg); stir until well-blended. Place beef mixture in an 8 x 4-inch loaf pan coated with cooking spray. Bake at 350° for 1 hour. Brush remaining ketchup mixture over top. Bake at 350° for 15 minutes. Let stand 10 minutes. Remove meat loaf from pan. Cut into 8 slices.