Preheat oven to 400°.
Cook beef, onion, and garlic in a large nonstick skillet over medium-high heat until beef is browned, stirring to crumble. Drain. Return to pan, and add Italian seasoning, salt, and pepper.
Unroll pizza crust onto an ungreased baking sheet. Cut dough into 4 squares. Press each square into a 6 x 5-inch rectangle. Spoon beef mixture evenly into center of each rectangle; sprinkle evenly with cheese. Bring opposite corners of rectangles together, pinching seams together to seal. Coat tops of calzones with cooking spray.
Bake at 400° for 11 minutes or until lightly browned. Place pasta sauce in a microwave-safe dish; microwave at HIGH 2 minutes or until thoroughly heated. Serve calzones with warm pasta sauce.