Combine pears and 1/3 cup sugar in a 3 1/2-quart saucepan. Cook, stirring often, over medium-low heat 12 to 14 minutes or until pears are tender. Remove from heat. (Drain excess liquid, if necessary.)
Process pears in a blender until smooth; stir in 2 tablespoons butter and vanilla. Set aside.
Line pie shell with aluminum foil; fill with pie weights or dried beans.
Bake on lowest oven rack at 425° for 10 minutes. Remove weights and foil; bake 4 more minutes.
Combine cheese and next 3 ingredients. Stir in 1/4 cup melted butter.
Spoon pear mixture into prepared piecrust; sprinkle with cheese mixture. Cover edges with aluminum foil.
Bake at 425° for 25 minutes.