Preheat oven to 425°.
Melt margarine in a 10-inch cast-iron skillet over medium-high heat. Add apple; sauté 3 minutes. Stir in brown sugar, cinnamon, and nutmeg; cook 2 minutes. Combine juice, water, and cornstarch in a small bowl. Stir well; add to skillet. Bring to a boil; cook 1 minute or until thick, stirring gently. Remove apple mixture from skillet; set aside, and keep warm. Wipe skillet clean with a paper towel.
Place skillet in oven for 5 minutes. Combine flour and 1 cup milk in a large bowl; stir well with a whisk. Stir in 1 cup milk, vanilla, and next 4 ingredients (vanilla through egg whites); set aside. Coat skillet with cooking spray; pour batter into preheated skillet. Bake at 425° for 25 minutes or until puffy and brown around edges. Remove from oven; sprinkle with powdered sugar. Cut into wedges; top with apple mixture. Serve immediately.